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Synthesis of Prodigiosene-Estrogen Conjugates: optimization of protecting group strategies and anticancer properties

dc.contributor.authorMarchal, Estelle
dc.contributor.authorUddin, Md. Imam
dc.contributor.authorHawco, Cassandra L. A.
dc.contributor.authorThompson, Alison
dc.date.accessioned2018-12-11T17:18:22Z
dc.date.available2018-12-11T17:18:22Z
dc.date.issued2015
dc.description- Post-print - Publisher copyright and source must be acknowledged (must include NRC Research Press' copyright notice) - Must link to publisher versionen_US
dc.description.abstractThe tripyrrolic prodigiosene skeleton was conjugated to several estrogen ligands. The conjugation was achieved via an ester linker that proved to be unusually sensitive to hydrolysis during synthesis. This work describes the determination of an appropriate protecting group for the hydroxy groups of the estrogen linker. The anticancer properties of the target prodigiosene-estrogen conjugates were evaluated against breast cancer cells and some show selectivity for ER+ breast cancer cell lines.en_US
dc.identifier.citationMarchal, E., Uddin, M. I., Hawco, C. L., & Thompson, A. (2015). Synthesis of prodigiosene–estrogen conjugates: optimization of protecting group strategies and anticancer properties. Canadian Journal of Chemistry, 93(5), 526-535. https://doi.org/10.1139/cjc-2014-0516en_US
dc.identifier.urihttp://hdl.handle.net/10222/75021
dc.publisherCanadian Journal of Chemistryen_US
dc.rightsNRC Research Press
dc.titleSynthesis of Prodigiosene-Estrogen Conjugates: optimization of protecting group strategies and anticancer propertiesen_US
dc.typeArticleen_US

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