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Synthesis of Prodigiosene-Estrogen Conjugates: optimization of protecting group strategies and anticancer properties

Date

2015

Authors

Marchal, Estelle
Uddin, Md. Imam
Hawco, Cassandra L. A.
Thompson, Alison

Journal Title

Journal ISSN

Volume Title

Publisher

Canadian Journal of Chemistry

Abstract

The tripyrrolic prodigiosene skeleton was conjugated to several estrogen ligands. The conjugation was achieved via an ester linker that proved to be unusually sensitive to hydrolysis during synthesis. This work describes the determination of an appropriate protecting group for the hydroxy groups of the estrogen linker. The anticancer properties of the target prodigiosene-estrogen conjugates were evaluated against breast cancer cells and some show selectivity for ER+ breast cancer cell lines.

Description

- Post-print - Publisher copyright and source must be acknowledged (must include NRC Research Press' copyright notice) - Must link to publisher version

Keywords

Citation

Marchal, E., Uddin, M. I., Hawco, C. L., & Thompson, A. (2015). Synthesis of prodigiosene–estrogen conjugates: optimization of protecting group strategies and anticancer properties. Canadian Journal of Chemistry, 93(5), 526-535. https://doi.org/10.1139/cjc-2014-0516

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