Synthesis of Prodigiosene-Estrogen Conjugates: optimization of protecting group strategies and anticancer properties
Date
2015
Authors
Marchal, Estelle
Uddin, Md. Imam
Hawco, Cassandra L. A.
Thompson, Alison
Journal Title
Journal ISSN
Volume Title
Publisher
Canadian Journal of Chemistry
Abstract
The tripyrrolic prodigiosene skeleton was conjugated to several estrogen ligands. The conjugation was achieved via an ester linker that proved to be unusually sensitive to hydrolysis during synthesis. This work describes the determination of an appropriate protecting group for the hydroxy groups of the estrogen linker. The anticancer properties of the target prodigiosene-estrogen conjugates were evaluated against breast cancer cells and some show selectivity for ER+ breast cancer cell lines.
Description
- Post-print
- Publisher copyright and source must be acknowledged (must include NRC Research Press' copyright notice)
- Must link to publisher version
Keywords
Citation
Marchal, E., Uddin, M. I., Hawco, C. L., & Thompson, A. (2015). Synthesis of prodigiosene–estrogen conjugates: optimization of protecting group strategies and anticancer properties. Canadian Journal of Chemistry, 93(5), 526-535. https://doi.org/10.1139/cjc-2014-0516