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Diagnostics and prospective outcome of a diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters after surgical resection (DGONC): a case report

Date

2022-10-25

Authors

Howie, Chelsea
Ahmad, Tahani
McFadden, Kathryn
Crooks, Bruce
McNeely, P Daniel
Walling, Simon
Rutledge, Robert
Sahm, Felix
Hinz, Felix
Jabado, Nada

Journal Title

Journal ISSN

Volume Title

Publisher

Oxford University Press

Abstract

Diffuse glioneuronal tumors with oligodendroglioma-like features and nuclear clusters (DGONC) are rare tumors of the central nervous system, having been added as a provi-sional diagnosis in the 2021 World Health Organization (WHO) Classification of Tumors of the central nervous system (CNS).1Retrospective studies report that these are most often mis-diagnosed and treated as high-grade tumors of the CNS.2,3However, this entity has demonstrated superior long-term survival in comparison. Given its novelty, there is currently no standard of care. We describe the diagnostic challenges, mo-lecular characteristics, prospective management, and outcome of a pediatric patient with a DGONC, with the aim to increase awareness of this entity and describe clinical behavior and di-agnostic uncertainties.

Description

Keywords

Citation

Howie C, Ahmad T, McFadden K, Crooks B, McNeely PD, Walling S, Rutledge R, Sahm F, Hinz F, Jabado N, Kieran M, Erker C. Diagnostics and prospective outcome of a diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters after surgical resection (DGONC): a case report. Neurooncol Adv. 2022 Oct 25;4(1):vdac170. doi: 10.1093/noajnl/vdac170. PMID: 36479060; PMCID: PMC9719366.