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Franklin, Tamara

Permanent URI for this collectionhttps://hdl.handle.net/10222/83467

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    Differential expression of Hdac2 in male and female mice of differing social status
    (Elsevier, 2024-01-01) Spiteri Douglas, Renee; Hartley, Mackenzie Rae; Franklin, Tamara Brook
    Mice naturally form social hierarchies and their experiences as subordinate or dominant mice inform future behavioural strategies. To better understand the neural bases of social dominance, we investigated hippocampal gene and protein expression of histone deacetylase 2 (HDAC2), an epigenetic regulator that decreases expression of synaptic plasticity genes and reduces excitatory synaptic function. Hdac2 in hippocampus was associated with social status. The gene for a closely related histone deacetylase (Hdac1), and HDAC2 protein expression, were not associated with social rank in hippocampus. These findings suggest that Hdac2 expression in hippocampus is distinctly linked with social status.
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    ItemOpen Access
    Aberrant cortical activity in 5xFAD mice in response to social and non-social olfactory stimuli (Postprint)
    (IOS Press, 2024-01-16) Kosel, Filip; Hartley, Mackenzie Rae; Franklin, Tamara Brook
    Background: Neuroimaging studies investigating the behavioural and psychological symptoms of dementia (BPSD)—such as apathy, anxiety, and depression— have linked some of these symptoms with altered neural activity. However, inconsistencies in operational definitions and rating scales, limited scope of assessments, and poor temporal resolution of imaging techniques have hampered human studies. Many transgenic (tg) mouse models of Alzheimer’s disease (AD) exhibit BPSD-like behaviours concomitant with AD-related neuropathology, allowing examination of how neural activity may relate to BPSD-like behaviours with high temporal and spatial resolution. Objective: To examine task-dependent neural activity in the mPFC of AD-model mice in response to social and non-social olfactory stimuli. Methods: We previously demonstrated age-related decreases in social investigation in tg 5xFAD females, and this reduced social investigation is evident in tg 5xFAD females and males by 6 months of age. In the present study, we examine local field potential (LFP) in the medial prefrontal cortex (mPFC) of awake, behaving 5xFAD females and males at 6 months of age during exposure to social and non-social odour stimuli in a novel olfactometer. Results: Our results indicate that tg 5xFAD mice exhibit aberrant baseline and task-dependent LFP activity in the mPFC—including higher relative delta (1-4Hz) band power and lower relative power in higher bands, and overall stronger phase-amplitude coupling—compared to wild-type controls. Conclusions: These results are consistent with previous human and animal studies examining emotional processing, anxiety, fear behaviours, and stress responses, and suggest that tg 5xFAD mice may exhibit altered arousal or anxiety.