Huguet, Anna
Permanent URI for this collectionhttps://hdl.handle.net/10222/72218
Anna Huguet
Adjunct Professor
Email: Anna.Huguet@iwk.nshealth.ca
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Item Open Access Systematic review of childhood and adolescent risk and prognostic factors for recurrent headaches(2016-08) Huguet, Anna; Tougas, Michelle E; Hayden, Jill; McGrath, Patrick J; Chambers, Christine T; Stinson, Jennifer N; Wozney, LoriLittle is known about childhood and adolescent risk and prognostic factors for recurrent headaches. This systematic review: (1) Examined longitudinal evidence about factors associated with onset and course of recurrent headaches in childhood or adolescence, using meta-analysis where possible; and (2) Evaluated the quality of this evidence using a modified GRADE framework. Through searching electronic databases, reference lists of included studies, and an electronic mail list we identified and included 23 articles reporting 19 cohorts. From the included studies we explored 27 risk factors for recurrent headaches, 27 prognostic factors for persistence of recurrent headaches, and 6 prognostic factors for presence of headache-related disability. The quality of evidence for most associations is low or very low. There is moderate quality evidence that females are at risk of developing recurrent headaches and of headaches persisting. There is high quality evidence suggesting that children with negative emotional states manifested through anxiety, depression or mental distress are not at risk of developing headache, but moderate quality evidence suggests that the presence of comorbid negative emotional states in children with headaches is associated with increased risk of headache persistence. Due to the small number of studies, further investigation is needed to increase confidence in existing evidence and to explore new risk and prognostic factors. Perspective: This is a review of the evidence about childhood and adolescent risk and prognostic factors for the onset of recurrent headaches and their course. Understanding these factors can help identify childrens’ risk and may suggest ways to reduce this risk.Item Open Access A Systematic Review with Meta-analysis of Childhood and Adolescent Risk and Prognostic Factors for Musculoskeletal Pain(2016-08-10) Huguet, Anna; Tougas, Michelle E; Hayden, Jill; McGrath, Patrick J; Stinson, Jennifer N; Chambers, Christine TA variety of factors may be involved in the development and course of musculoskeletal (MSK) pain. We undertook a systematic review with meta-analysis to synthesize and evaluate the quality of evidence about childhood and adolescent factors associated with onset and persistence of MSK pain, and its related disability. Studies were identified from searches of electronic databases (PubMed, EMBASE, PsycINFO, CINAHL, and Web of Science), references of included studies, and the Pediatric Pain mail list. Two independent reviewers assessed study inclusion, completed data extraction and evaluated the quality of evidence using a modified GRADE framework. Thirty-six studies reporting on 21 cohorts were included. These studies examined 65 potential risk factors for onset of MSK pain and 43 potential prognosis factors for persistence of MSK pain. No study was identified that examined prognostic factors for MSK pain-related disability. High quality evidence suggests that low socioeconomic status is a risk factor for onset of MSK pain in studies exploring long-term follow-up. Moderate quality evidence suggests that negative emotional symptoms and regularly smoking in childhood or adolescence may be associated with later MSK pain. However, moderate quality evidence also suggests that high BMI, taller height and having joint hypermobility are not risk factors for onset of MSK pain. We found other risk and prognostic factors explored were associated with low or very low quality of evidence. Additional well-conducted primary studies are needed to increase confidence in the available evidence, and to explore new childhood risk and prognostic factors for MSK pain.