Lipophilic sugar nucleotide synthesis by structure-based design of nucleotidylyltransferase substrates
Date
2008-02
Authors
Huestis, Malcolm P.
Aish, Gaia A.
Hui, Joseph P. M.
Soo, Evelyn C.
Jakeman, David L.
Journal Title
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Volume Title
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Abstract
Structure-based design of alkyl sugar-1-phosphates provides an efficient
nucleotidylyltransferase-catalyzed synthesis of a series of new lipophilic sugar nucleotides
possessing long or branched alkyl chains, thereby demonstrating the utility of
nucleotidylyltransferases to catalyze the synthesis of sugar nucleotides with potential applications
in lipopolysaccharide and lipoglycopeptide biosynthesis.
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Citation
Huestis, Malcolm P., Gaia A. Aish, Joseph P. M. Hui, Evelyn C. Soo, et al. 2008. "Lipophilic sugar nucleotide synthesis by structure-based design of nucleotidylyltransferase
substrates." Organic & Biomolecular Chemistry 6(3): 477-484.