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Positive Darwinian Selection in the Piston That Powers Proton Pumps in Complex I of the Mitochondria of Pacific Salmon

dc.contributor.authorGarvin, Michael R.en_US
dc.contributor.authorBielawski, Joseph P.en_US
dc.contributor.authorGharrett, Anthony J.en_US
dc.date.accessioned2013-07-04T18:42:27Z
dc.date.available2013-07-04T18:42:27Z
dc.date.issued2011-09en_US
dc.description.abstractThe mechanism of oxidative phosphorylation is well understood, but evolution of the proteins involved is not. We combined phylogenetic, genomic, and structural biology analyses to examine the evolution of twelve mitochondrial encoded proteins of closely related, yet phenotypically diverse, Pacific salmon. Two separate analyses identified the same seven positively selected sites in ND5. A strong signal was also detected at three sites of ND2. An energetic coupling analysis revealed several structures in the ND5 protein that may have co-evolved with the selected sites. These data implicate Complex I, specifically the piston arm of ND5 where it connects the proton pumps, as important in the evolution of Pacific salmon. Lastly, the lineage to Chinook experienced rapid evolution at the piston arm.en_US
dc.identifier.citationGarvin, Michael R., Joseph P. Bielawski, and Anthony J. Gharrett. 2011. "Positive Darwinian Selection in the Piston That Powers Proton Pumps in Complex I of the Mitochondria of Pacific Salmon." Plos One 6(9): 24127-e24127.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.issue9en_US
dc.identifier.startpage24127en_US
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0024127en_US
dc.identifier.urihttp://hdl.handle.net/10222/28739
dc.identifier.volume6en_US
dc.relation.ispartofPlos Oneen_US
dc.titlePositive Darwinian Selection in the Piston That Powers Proton Pumps in Complex I of the Mitochondria of Pacific Salmonen_US
dc.typearticleen_US

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