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Sex differences in experimental pain among healthy children: A systematic review and meta-analysis

dc.contributor.authorBoerner, Katelynn Elizabeth
dc.contributor.authorBirnie, Kathryn A
dc.contributor.authorCaes, Line
dc.contributor.authorSchinkel, Meghan
dc.contributor.authorChambers, Christine
dc.date.accessioned2018-12-04T16:52:14Z
dc.date.available2018-12-04T16:52:14Z
dc.date.issued2014
dc.description.abstractSex differences in response to experimental pain are commonly reported in systematic reviews in the adult literature. The objective of the present research was to conduct a systematic review and meta-analysis of sex differences in healthy children’s responses to experimental pain (e.g., cold pressor, heat pain, pressure pain) and, where possible, to conduct analyses separately for children and adolescents. A search was conducted of electronic databases for published papers in English of empirical research using experimental pain tasks to examine pain-related outcomes in healthy boys and girls between 0 and 18 years of age. Eighty articles were eligible for inclusion and were coded to extract information relevant to sex differences. The systematic review indicated that, across different experimental pain tasks, the majority of studies reported no significant differences between boys and girls on pain-related outcomes. However, the meta-analysis of available combined data found that girls reported significantly higher pain intensity compared to boys in studies where the mean age of participants was greater than 12 years. Additionally, a meta-analysis of heat pain found that boys had significantly higher tolerance than girls overall, and boys had significantly higher heat pain threshold than girls in studies where the mean age of participants was 12 years or younger. These findings suggest that developmental stage may be relevant for understanding sex differences in pain.en_US
dc.identifier.citationBoerner, K.E., Birnie, K.A., Caes, L., Schinkel, M., & Chambers, C.T. (2014). Sex differences in experimental pain among healthy children: A systematic review and meta-analysis. PAIN, 155, 983-993en_US
dc.identifier.urihttp://hdl.handle.net/10222/75002
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofPAINen_US
dc.titleSex differences in experimental pain among healthy children: A systematic review and meta-analysisen_US
dc.typeManuscripten_US

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