dc.contributor.author | Willett, Natalie | |
dc.date.accessioned | 2024-08-23T14:57:14Z | |
dc.date.available | 2024-08-23T14:57:14Z | |
dc.date.issued | 2024-08-21 | |
dc.identifier.uri | http://hdl.handle.net/10222/84453 | |
dc.description.abstract | Frailty can be defined as a state of vulnerability to adverse health events. In this project, a standardized method for constructing a frailty index was followed using data from the SPOR IMAGINE IBD cohort. We constructed an IBD 77 item Frailty Index (FI) using a validated 10 step process using baseline data from 2714 participants. The histogram of FI scores showed a right skew, which is characteristic of an FI. In this distribution the upper limit (99th percentile) of FI score is 0.529 displaying a submaximal limit, characteristic of other valid FIs. The mean FI score was higher in women. The mean age of our cohort was 45.8 years old (SD: 15), and the mean FI score was 0.17 (SD: 0.12), lower than that for other immune mediated diseases, and 30.6% of our sample was categorized as frail (FI score >0.21). FI scores were associated with IBD symptom severity (R=0.767). | en_US |
dc.language.iso | en | en_US |
dc.subject | Crohn's disease | en_US |
dc.subject | Ulcerative colitis | en_US |
dc.subject | Inflammatory bowel disease | en_US |
dc.subject | frailty | en_US |
dc.title | Construction and Validation of a Frailty Index for the Inflammatory Bowel Disease Population | en_US |
dc.date.defence | 2024-07-24 | |
dc.contributor.department | Department of Community Health & Epidemiology | en_US |
dc.contributor.degree | Master of Science | en_US |
dc.contributor.external-examiner | n/a | en_US |
dc.contributor.thesis-reader | Dr. Kenneth Rockwood | en_US |
dc.contributor.thesis-reader | Dr. Olga Theou | en_US |
dc.contributor.thesis-supervisor | Dr. Jennifer Jones | en_US |
dc.contributor.thesis-supervisor | Dr. Samuel Stewart | en_US |
dc.contributor.ethics-approval | Received | en_US |
dc.contributor.manuscripts | Not Applicable | en_US |
dc.contributor.copyright-release | Not Applicable | en_US |