dc.contributor.author | Glazebrook, Jonah | |
dc.date.accessioned | 2023-11-08T15:35:50Z | |
dc.date.available | 2023-11-08T15:35:50Z | |
dc.date.issued | 2023-10-26 | |
dc.identifier.uri | http://hdl.handle.net/10222/83077 | |
dc.description | This thesis work sought to develop a novel trauma wound dressing with enhanced hemostatic and antibacterial properties using chitosan, polyphosphate and copper. A production protocol for such a material was developed and optimized using a design of experiments approach in this thesis. The material was extensively characterized and compared using trauma relevant outcome measures to a chitosan-only mesh and commercial trauma wound dressing. | en_US |
dc.description.abstract | The primary focus when treating traumatic wounds is to control bleeding. Once hemostasis is achieved, the priority shifts to preventing infection. Wound dressings, predominantly gauze, are used for initial on-site treatment but typically lack additional hemostatic or antibacterial effects. This thesis aims to create a material with enhanced hemostatic and antibacterial effects for trauma wound dressing through polyelectrolyte complexation of chitosan (CS), polyphosphate (PP) and copper followed by lyophilization. A consistent production protocol for synthesizing the CS-PP-Cu mesh-like material was developed. A design of experiments (DoE) approach with predictive modelling was subsequently undertaken to optimize key process variables (factors) according to relevant outcome measures (responses) crucial to wound dressing performance. Along with validating the DoE models, these optimized material formulations were used to verify the potential effectiveness of the CS-PP-Cu material as a trauma wound dressing relative to commercial wound dressing (Celox™) and CS-only mesh. | en_US |
dc.language.iso | en | en_US |
dc.subject | Wound Dressing | en_US |
dc.subject | Trauma Treatment | en_US |
dc.subject | Chitosan | en_US |
dc.subject | Polyphosphate | en_US |
dc.subject | Design of Experiments | en_US |
dc.subject | Copper | en_US |
dc.title | Design of Experiments Approach for Optimizing a Chitosan-Polyphosphate-Copper Based Material for Trauma Wound Treatment | en_US |
dc.date.defence | 2023-10-03 | |
dc.contributor.department | School of Biomedical Engineering | en_US |
dc.contributor.degree | Master of Applied Science | en_US |
dc.contributor.external-examiner | Dr. Vahid Adibnia | en_US |
dc.contributor.thesis-reader | Dr. Brendan Leung | en_US |
dc.contributor.thesis-reader | Dr. Daniel Boyd | en_US |
dc.contributor.thesis-supervisor | Dr. Mark Filiaggi | en_US |
dc.contributor.ethics-approval | Not Applicable | en_US |
dc.contributor.manuscripts | Not Applicable | en_US |
dc.contributor.copyright-release | Not Applicable | en_US |