dc.contributor.author | Clifton, Kerry-Lee | |
dc.date.accessioned | 2021-04-12T13:11:25Z | |
dc.date.available | 2021-04-12T13:11:25Z | |
dc.date.issued | 2021-04-12T13:11:25Z | |
dc.identifier.uri | http://hdl.handle.net/10222/80374 | |
dc.description.abstract | Background: The objective of this study was to determine the relationship between frailty and the development and progression of HIV-Associated Neurocognitive Disorder (HAND).
Methods: This study used data from the Ontario HIV Treatment Network (OHTN) Cohort Study.
Results: Higher FI scores were associated with increased risk of development of HAND (HR 1.68, 95% CI 1.00 – 2.87, p=0.048 for FI Scores 0.10 to 0.19; HR 1.75, 95% CI 1.04 – 2.92, p=0.034 for FI Score 0.20 to 0.29; and HR 2.27, 95% CI 1.36 – 3.81, p=0.002 for FI Score 0.30+). High frailty at baseline was associated with shorter progression time to HAND. The Determinant Index mobility measure demonstrated that non-frail and high frailty participants had significantly lower mobility between HAND states than those with low and moderate frailty.
Conclusion: The frailty index was useful in predicting the development of HAND and the mobility between various HAND states. | en_US |
dc.language.iso | en | en_US |
dc.subject | HIV | en_US |
dc.subject | Frailty | en_US |
dc.subject | Aging | en_US |
dc.subject | HAND | en_US |
dc.subject | HAD | en_US |
dc.title | The relationship between frailty and the development and progression of HIV-Associated Neurocognitive Disorder (HAND) | en_US |
dc.type | Thesis | en_US |
dc.date.defence | 2021-01-07 | |
dc.contributor.department | Department of Community Health & Epidemiology | en_US |
dc.contributor.degree | Master of Science | en_US |
dc.contributor.external-examiner | n/a | en_US |
dc.contributor.graduate-coordinator | Dr. Yukiko Asada | en_US |
dc.contributor.thesis-reader | Dr. Olga Theou | en_US |
dc.contributor.thesis-reader | Dr. Pantelis Andreou | en_US |
dc.contributor.thesis-supervisor | Dr. Susan Kirkland | en_US |
dc.contributor.ethics-approval | Not Applicable | en_US |
dc.contributor.manuscripts | Not Applicable | en_US |
dc.contributor.copyright-release | Not Applicable | en_US |