dc.contributor.author | Paquet, Nicole | |
dc.date.accessioned | 2020-04-13T14:27:15Z | |
dc.date.available | 2020-04-13T14:27:15Z | |
dc.date.issued | 2020-04-13T14:27:15Z | |
dc.identifier.uri | http://hdl.handle.net/10222/78446 | |
dc.description.abstract | The study objectives were to estimate the association between mammographic breast density (MBD) and triple negative breast cancers (TNBC); as well as to estimate the discriminatory ability of MBD, alone and with clinical risk factors, in the screening population. This case-control study consisted of 121 TNBC cases with a full-field digital mammography (FFDM) screen in 2009-2015 in Nova Scotia. The 6807 controls were women with a prior negative FFDM screening mammogram episode. Odds ratios and areas under curves were reported for models generated using two measures of MBD, percent and BI-RADS categories (5th ed.), both separately and in combination. Aside from the two forms of MBD, other variables included self-reported risk factors (menopausal status, hormone replacement therapy use, parity, family history), biopsy history, and derived breast volume. A significant positive association was found between MBD and TNBC in this screening population. The addition of clinical factors to density improved the discriminatory ability of the prediction models. | en_US |
dc.language.iso | en | en_US |
dc.subject | Breast Density | en_US |
dc.subject | Triple Negative Breast Cancer | en_US |
dc.subject | Breast Cancer Screening | en_US |
dc.title | Investigating the relationship between mammographic breast density and triple negative breast cancer in Nova Scotia, Canada | en_US |
dc.date.defence | 2020-03-02 | |
dc.contributor.department | Department of Community Health & Epidemiology | en_US |
dc.contributor.degree | Master of Science | en_US |
dc.contributor.external-examiner | N/A | en_US |
dc.contributor.graduate-coordinator | Yukiko Asada | en_US |
dc.contributor.thesis-reader | Christy Woolcott | en_US |
dc.contributor.thesis-reader | Mohamed Abdolell | en_US |
dc.contributor.thesis-supervisor | Jennifer Payne | en_US |
dc.contributor.thesis-supervisor | Susan Kirkland | en_US |
dc.contributor.ethics-approval | Received | en_US |
dc.contributor.manuscripts | Not Applicable | en_US |
dc.contributor.copyright-release | Not Applicable | en_US |