dc.contributor.author | Gendron, William | |
dc.date.accessioned | 2015-08-19T13:07:43Z | |
dc.date.available | 2015-08-19T13:07:43Z | |
dc.date.issued | 2015 | |
dc.identifier.uri | http://hdl.handle.net/10222/60526 | |
dc.description.abstract | The 5xFAD mice exhibit weight loss at 9 months of age. We investigated age-related changes in body weight, feeding behaviour, activity levels, feeding-related hormones, and proteins regulating adipogenesis and thermogenesis in female 5xFAD mice and their WT controls. The 5xFAD mice were hypoactive in climbing and rearing (p<0.05), and were frequently still (p<0.05). Differences in food intake and body weight occurred at 9 and 12 months of age, where WT ate and weighed more (p<0.05). The 5xFAD mice had less white adipose tissue (WAT); p<0.05). Expression of leptin mRNA, UCP-2, UCP-1, and HSL were measured in WAT and did not differ between genotypes (p<0.05). Transgenic mice expressed more UCP-1 (p<0.05). At 9 and 12 months of age, the 5xFAD mice ate less, had a lower body weight and were hypoactive. At 12 months of age the 5xFAD mice had less body fat and expressed less leptin, UCP-2, and HSL mRNA. | en_US |
dc.language.iso | en | en_US |
dc.subject | Alzheimer's disease | en_US |
dc.subject | Ageing | en_US |
dc.subject | Metabolism | en_US |
dc.title | AGE-RELATED WEIGHT LOSS IN THE 5XFAD MOUSE MODEL OF ALZHEIMER’S DISEASE: A BEHAVIOURAL AND HORMONAL ANALYSIS | en_US |
dc.type | Thesis | en_US |
dc.date.defence | 2015-07-07 | |
dc.contributor.department | Neuroscience | en_US |
dc.contributor.degree | Master of Science | en_US |
dc.contributor.external-examiner | n/a | en_US |
dc.contributor.graduate-coordinator | Gail Eskes | en_US |
dc.contributor.thesis-reader | Tara Perrot | en_US |
dc.contributor.thesis-reader | Younes Anini | en_US |
dc.contributor.thesis-supervisor | Richard Brown | en_US |
dc.contributor.ethics-approval | Received | en_US |
dc.contributor.manuscripts | Not Applicable | en_US |
dc.contributor.copyright-release | Not Applicable | en_US |