dc.contributor.author | Li, Frederick Wai-Tsin | |
dc.date.accessioned | 2011-04-15T14:01:28Z | |
dc.date.available | 2011-04-15T14:01:28Z | |
dc.date.issued | 2011-04-15 | |
dc.identifier.uri | http://hdl.handle.net/10222/13362 | |
dc.description.abstract | Although the perifornical lateral hypothalamic area (PeFLH), which contains orexin/hypocretin (OX) neurons, plays an important role in arousal-related behaviors, its neuromodulatory inputs are incompletely understood. The present study examined the role of glutamatergic inputs to the PeFLH in various arousal-related behaviors. Adult male rats received a microinjection of the ionotropic glutamate receptor agonists AMPA (1 and 2 mM) or NMDA (1 and 10 mM), or vehicle into the PeFLH, and were placed in an open field; 90 min later, rats were perfused for immunohistochemistry for OX and c-Fos as a marker of neuronal activation. AMPA injections dose-dependently increased locomotion, rearing, and drinking. NMDA injections (at 10 mM) increased locomotion and feeding. All these behaviors (except feeding) were positively correlated with the number of c-Fos/OX-immunoreactive neurons. These results support the role of ionotropic glutamate receptors on OX (and other) neurons in the PeFLH in the regulation of locomotor and ingestive behaviors. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | orexin | en_US |
dc.subject | locomotor activity | en_US |
dc.subject | feeding/drinking | en_US |
dc.subject | c-Fos | en_US |
dc.title | ANALYSIS OF BEHAVIORAL AND NEURONAL ACTIVATION FOLLOWING AMPA AND NMDA MICROINJECTIONS INTO THE PERIFORNICAL LATERAL HYPOTHALAMIC AREA IN RATS | en_US |
dc.date.defence | 2011-01-28 | |
dc.contributor.department | Department of Anatomy & Neurobiology | en_US |
dc.contributor.degree | Master of Science | en_US |
dc.contributor.external-examiner | Dr. Jennifer Stamp | en_US |
dc.contributor.graduate-coordinator | Dr. Kazue Semba | en_US |
dc.contributor.thesis-reader | Dr. John Rutherford | en_US |
dc.contributor.thesis-reader | Dr. Douglas Rasmusson | en_US |
dc.contributor.thesis-supervisor | Dr. Kazue Semba | en_US |
dc.contributor.ethics-approval | Not Applicable | en_US |
dc.contributor.manuscripts | No | en_US |
dc.contributor.copyright-release | No | en_US |