Browsing by Subject "ligand design"
Now showing items 1-5 of 5
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Advances in Nickel-Catalyzed C-N Cross-Coupling Enabled by Tailored Ancillary Ligand Design
(2018-12-05)The nickel-catalyzed Csp2-N cross-coupling of NH substrates and (hetero)aryl (pseudo)halides for the synthesis of (hetero)anilines is in the midst of a resurgence. Reactivity breakthroughs that have been achieved in this ... -
Advances in Nickel-Catalyzed C–O Cross-Coupling Reactions Enabled by Ancillary Ligand Design
(2023-12-04)The ubiquity of C(sp2)–N and C(sp2)–O linkages in active pharmaceutical ingredients, agrochemicals, and other biologically active compounds generates motivation for developing effective avenues for the formation of such ... -
Challenging Nickel-Catalyzed Cross-Couplings Enabled by Ligand Design
(2022-04-05)Carbon-nitrogen linkages are highly prevalent in bioactive molecules, and as such, the development of sustainable methodologies for their formation is of immense importance to both the pharmaceutical and agricultural ... -
Expanding the Scope of Nickel-Catalyzed C(sp2)–N/O Cross-Coupling Reactions Using Tailored Ancillary Ligands
(2021-01-18)The ubiquity of aryl C–N/O bonds in pharmaceuticals and natural products necessitates the development of robust and selective methodologies to construct such linkages efficiently. Palladium-catalyzed C(sp2)–N/O cross-coupling ... -
Investigating the Design of Bisphosphine Ligands for use in Nickel-catalyzed C(sp2)-N Cross-Coupling
(2019-12-13)Notwithstanding the matured protocol of palladium-catalyzed C(sp2)-N cross-coupling (Buchwald Hartwig Amination, BHA), the development of nickel-based catalysts that carry out analogous transformations is motivated both ...