Browsing by Subject "inflammation"
Now showing items 1-9 of 9
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BRIDGING THE GAP BETWEEN BASIC SCIENCE AND CLINICAL TRANSLATION: UNDERSTANDING THE ASSOCIATIONS BETWEEN MONOCYTES/MACROPHAGES AND INFLAMMATION IN PATIENTS UNDERGOING CARDIAC SURGERY
(2018-04-03)Cardiovascular disease (CVD) is the leading cause of death worldwide. Work from our lab group and others has shown that monocytes/macrophages are key mediators in the inflammatory response involved in CVD and the development ... -
The Effects of Endocannabinoid Modulation and Neurogenic Inflammation in Experimental Knee Joint Arthritis
(2015)Arthritis is a debilitating condition, and a leading cause of disability worldwide. Despite the prevalence of arthritis, few therapies are satisfactorily efficacious, and many are limited by serious adverse effects. It is ... -
Endocannabinoid system modulation of the ocular immune response
(2015)The endocannabinoid system (ECS) is an endogenous lipid signaling system, comprised of receptors, ligands, and their degradative enzymes. The cannabinoid 2 receptor (CB2R) is localized on immune cells and modulates immune ... -
From Fibrocyte Migration To Resident Cardiac Macrophage Phenotypes: The Evolution In Understanding of Macrophages In Non-Ischemic Myocardial Injury and Fibrosis
(2016-08-03)Heart failure is a growing societal and healthcare issue for which the only long-term therapy is transplantation. Heart failure therapies have been limited by our understanding of a key process involved in healing termed ... -
Impact of Species-Specific Lactoferricin Peptides on Macrophage-Associated Inflammatory Processes
(2018-01-05)Inflammation is the body’s response to injury or infection and is important for elimination of the infecting agent and healing. However, prolonged inflammation can be damaging and may lead to the development of chronic ... -
Investigation of Phyto-, Endo-, and Syntheto-cannabinoids in the Management of Osteoarthritis Pain and Inflammation in Rats
(2017-12-08)The most prevalent form of joint disease, osteoarthritis (OA), is characterised by joint destruction, pain, and intermittent inflammation. It has recently emerged that OA is also associated with damage to the sensory nerves ... -
Iron-related immune cell function in sepsis
(2019-10-04)Sepsis is characterized by a dysregulated immune response to infection, causing damage to tissues and organs. As part of the inflammatory response, iron catalyzes the generation of reactive oxygen species (ROS). In the ... -
PHYTOCANNABINOID BETA-CARYOPHYLLENE MODULATES INFECTION AND INFLAMMATION IN IN VITRO AND MURINE MODELS OF URINARY TRACT INFECTION
(2024-08-12)Urinary tract infections (UTIs) are common infections, placing significant burdens on both patients and the healthcare system. Though antibiotics usually clear UTIs, they do not address pain and inflammation. The terpene, ... -
POTENTIAL ROLE OF IRON CHELATION IN EXPERIMENTAL SEPSIS
(2019-12-19)Sepsis is a life-threatening medical condition characterized by a dysregulated immune response to an infection. The increasing incidence, remaining high mortality and enormous costs burden, make sepsis a real public health ...