Browsing by Subject "Shigella"
Now showing items 1-5 of 5
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APPLICATIONS AND CHARACTERIZATION OF A STREPTOMYCIN MOUSE MODEL FOR SHIGELLOSIS
(2016-08-02)Shigella flexneri is the causative agent of dysentery. An oral murine infection model, that uses the broad-spectrum antibiotic streptomycin prior to Shigella infection, has been established and displays hallmarks of Shigella ... -
Mechanisms by which Shigella flexneri impairs dendritic cell function: silencing the link between innate and adaptive immunity
(2015)Shigella flexneri is a Gram-negative bacterial pathogen that causes severe gastroenteritis in humans. Upon infection, Shigella invades the host colonic epithelium using a type III secretion system (T3SS) that is encoded ... -
Shigella Effector IpaH9.8 Modulates a Host Ubiquitin-Like Pathway and Lysosomal Biogenesis
(2020-01-21)The bacterium Shigella causes bacterial dysentery in developing countries and represents a persistent burden to healthcare systems due to an increase in antibiotic-resistant strains and lack of a vaccine strategy. Shigella ... -
SHIGELLA FLEXNERI REQUIRES THE HOST SCAFFOLD PROTEIN RACK1 TO MODULATE ACTIN POLYMERIZATION, PROMOTING INFECTION
(2022-04-29)Shigella flexneri, the causative agent of the acute diarrheal disease shigellosis, manipulates the host actin cytoskeleton to infect intestinal epithelial cells (ECs). Shigella secretes bacterial effectors into the EC ... -
TOOLS FOR IDENTIFYING FUNCTIONS OF TYPE III SECRETION SYSTEM EFFECTORS FROM SHIGELLA FLEXNERI
(2013-06-18)Shigellae are pathogenic bacteria that cause the disease shigellosis. Two methods for studying secreted effectors encoded by this pathogen’s virulence plasmid are described. First, protein microarrays were used to identify ...