Browsing by Subject "Reovirus"
Now showing items 1-4 of 4
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CHARACTERIZING THE EFFECT OF COLONY STIMULATING FACTORS ON MACROPHAGE METABOLISM AND PHENOTYPE
(2023-08-24)Macrophages are a highly specialized group of immune cells and often referred to as sentinels of the immune system due to their ability to phagocytose cellular debris and pathogens, detect danger signals, and produce ... -
FAST-Mediated Pore Expansion: Novel Roles For Annexin A1 and Plasma Membrane Architecture
(2016-01-19)Two approaches investigating the contribution of cellular factors to syncytiogenesis mediated by viral fusogens are reported in this thesis. These include architecture of plasma membrane curvature and the role of annexin ... -
Molecular Mechanisms of Reovirus Oncolysis
(2013-02-06)Mammalian reovirus is a naturally benign virus that preferentially replicates in cancer cells (reovirus oncolysis) and has been tested as a potential cancer therapy in vitro, in vivo and in clinical trials for treating ... -
Oncolytic Reovirus Induces Intracellular Redistribution of Ras to Promote Apoptosis and Progeny Virus Release
(2014-08-22)Ras is a dynamic protein capable of interacting with plasma membrane microdomains and intracellular membranes. Its activity, as controlled by post-translational modifications, is essential in regulating cell growth, ...