Browsing by Subject "PRP4K"
Now showing items 1-4 of 4
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ESTROGEN RECEPTOR ALPHA SIGNALLING REGULATES THE EXPRESSION OF THE TAXANE-RESPONSE BIOMARKER PRP4K
(2018-01-05)The hormone estrogen, when bound to its receptor (ER) triggers a cascade of signalling events that result in the proliferation of normal mammary glands. This hormone can also regulate gene expression at the transcriptional ... -
Linking PRP4K Cytoplasmic Functions to Tumour Suppression
(2021-06-18)Breast cancer is one of the most common cancers faced by Canadian women today. These carcinomas arise from epithelial cells in mammary tissue, and therefore processes and signaling pathways that regulate tissue homeostasis ... -
Loss of PRP4K is linked to anoikis resistance and partial epithelial-to-mesenchymal transition
(2021-01-12)Metastatic disease is the primary cause of cancer-related death, and as a result the metastatic potential of a tumor is an important indicator of patient survival. For tumor cells to metastasize, they must overcome a special ... -
The Role of PRP4K as a Tumor Suppressor in Lewis Lung Carcinoma Cells
(2021-01-12)Although originally identified as a splicing kinase, recent data indicates that pre-mRNA processing factor kinase 4 (PRP4K) may promote metastasis by a partial epithelial-to mesenchymal transition (EMT) phenotype. Thus, ...