Browsing by Subject "PML"
Now showing items 1-3 of 3
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AN INVESTIGATION OF NUCLEAR LIPID DROPLET BIOGENESIS IN CELL CULTURE AND ORGANOID MODELS.
(2024-07-12)Lipid droplets (LDs) are dynamic organelles central to lipid storage and metabolic homeostasis in eukaryotic cells. In lipid-loaded cells, LD biogenesis primarily occurs in the ER membrane yielding cytoplasmic LDs, but ... -
AN INVESTIGATION OF THE NUCLEAR LIPID ASSOCIATED PROMYELOCYTIC LEUKEMIA (PML) STRUCTURES (LAPS) PROTEOME USING BIOTIN PROXIMITY LABELLING
(2022-08-30)Fatty acids are stored in triacyl glycerides or cholesterol esters in lipid droplets (LDs). While most LDs are cytoplasmic, there are also nuclear lipid droplets (nLDs) that associate with promyelocytic leukemia (PML) ... -
The molecular evolution of DEDDh exonucleases reveals novel functions in innate immune signalling
(2023-12-01)The Promyelocytic Leukemia (PML) protein is the major constituent of PML nuclear bodies (NBs), a subnuclear compartment involved in regulating a diverse array of cellular processes. PML NBs have tumour suppressive functions ...