Browsing by Subject "Osteoarthritis"
Now showing items 1-11 of 11
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Arthrocen & OA Pain Raw Data
(2018-01-25) -
CHARACTERISING THE NEUROPHYSIOLOGY OF POST-TRAUMATIC OSTEOARTHRITIS IN RATS AND THE INVOLVEMENT OF PROTEASE ACTIVATED RECEPTOR-4
(2021-03-18)Osteoarthritis (OA) affects 1 in 10 Canadians and is more prevalent in women than men. Remarkably, 60% of OA patients cite inadequate pain relief with current treatments. This may in part be due to multiple OA phenotypes ... -
Data Science Strategies for Modelling Total Knee Arthroplasty Patient Variability
(2021-03-30)Knee osteoarthritis (OA) can present through self-reported patient symptoms and joint-level manifestations, impairing mobility and function. Symptom relief and functional restoration of end-stage OA is typically treated ... -
The effect of knee joint effusion on gait mechanics and muscle activation characteristics in moderate knee osteoarthritis
(2018-08-29)Knee osteoarthritis (OA) is one of the most prevalent joint diseases, and knee effusion, as a manifestation of synovitis, is associated with knee OA clinical outcomes and disease progression. Thesis objectives were i) to ... -
Factors affecting knee joint muscle activation patterns during gait in individuals with knee osteoarthritis
(2012-01-03)Knee osteoarthritis (OA) is a progressive disease and a leading cause of morbidity in older adults, resulting in severe mobility limitations. While the osteoligamentous and neuromuscular systems are altered in knee OA, ... -
Innovative Clinical Tools for Objectively Measuring Longitudinal Changes in Knee Arthroplasty Patient Gait Kinematics Awaiting Surgery
(2024-04-22)Current clinical management of end-stage knee OA lacks objective functional assessments of patients. Markerless motion capture systems are a new technology that have the potential to facilitate efficient, well-integrated ... -
KNEE MECHANICS OF HEALTHY AND OSTEOARTHRITIC JOINTS
(2019-12-17)Objective: Knee Osteoarthritis (OA) can be the result of both mechanical and biological events that interfere with normal joint function. The aims of this thesis were to (1) quantify the biomechanical factors that ... -
Lower Limb Biomechanics in Response to Unexpected Walking Surface Translations During Gait in Individuals with Knee Osteoarthritis: A Comparison Study to Healthy Asymptomatic Individuals
(2023-08-29)Knee osteoarthritis is a prevalent musculoskeletal condition affecting mobility and function. Walking surface perturbations unpredictably challenge individuals to test joint function. Thesis’ objectives were to determine ... -
OBESITY AND ITS INFLUENCE ON KNEE JOINT CONTACT FORCES IN INDIVIDUALS WITH MODERATE KNEE OSTEOARTHRITIS
(2014-08-22)Obesity is known as a major risk factor for the development and progression of knee OA. It has been proposed to affect the joint through linked mechanical and metabolic factors. However, its precise role in the pathomechanics ... -
Obesity is associated with higher absolute tibiofemoral contact and muscle forces during gait with and without knee osteoarthritis
(Elsevier, 2016-01)Background Obesity is an important risk factor for knee osteoarthritis initiation and progression. However, it is unclear how obesity may directly affect the mechanical loading environment of the knee joint, initiating ... -
Physical Activity Tracking for End-Stage Knee Osteoarthritis Patients Seeking Joint Replacement Surgery
(2023-07-31)The purpose of this thesis was to explore the relationships between physical activity levels (in terms of step counts and sedentary behaviors) and patient-specific characteristics in a population of end-stage knee ...