Browsing by Subject "Influenza"
Now showing items 1-6 of 6
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The Association between Prior Seasonal Influenza Vaccination and Subsequent Seasonal Influenza Vaccine Effectiveness in Canada
(2016-08-29)Influenza is a major burden to the health of thousands of Canadians every year. Recent observational studies have suggested that prior influenza vaccination could impact subsequent influenza vaccine effectiveness (VE) under ... -
Attitudes Towards Influenza Vaccination During "Wait Times" in the Emergency Department
(2019-04-05)Influenza is a burdensome and preventable infectious disease. Lack of time was the reported reason 15% of Canadians did not receive their influenza vaccine in 2016/2017. Meanwhile, emergency department (ED) wait times are ... -
CHARACTERIZING HOST TARGETED ANTIVIRALS THAT IMPAIR INFLUENZA A VIRUS PROTEIN SYNTHESIS
(2021-10-22)The plasticity of influenza A virus (IAV) genomes enables rapid evolution of resistance to antivirals that directly target viral proteins. By contrast, host-targeted antivirals have the potential to disrupt key steps in ... -
FAST-Mediated Pore Expansion: Novel Roles For Annexin A1 and Plasma Membrane Architecture
(2016-01-19)Two approaches investigating the contribution of cellular factors to syncytiogenesis mediated by viral fusogens are reported in this thesis. These include architecture of plasma membrane curvature and the role of annexin ... -
INFLUENZA A VIRUS INFECTION AND UFMYLATION
(2024-06-23)This thesis investigates the interplay between UFMylation, a post-translational modification involving the conjugation of the ubiquitin-like protein Ubiquitin-fold modifier 1 (UFM1) to target proteins, and the replication ... -
Three Essays on the Economics of Health and Well-Being
(2018-04-30)This dissertation offers three vignettes on the determinants of health and well-being over the life course. The first essay uses multiple Canadian census files to document the longterm effects of potential in utero exposure ...