Browsing by Subject "Huntington's disease"
Now showing items 1-2 of 2
-
CANNABINOIDS REGULATE TYPE 1 CANNABINOID RECEPTOR EXPRESSION IN CELL CULTURE MODELS OF HUNTINGTON'S DISEASE
(2012-08-10)Type 1 cannabinoid receptor (CB1) levels decline in the striatum of animal models of Huntington’s disease (HD) and in the brains of human patients suffering from HD prior to other pathogenic changes. CB1 levels can be ... -
Overexpressing Fragments of CREB-Binding Protein (CBP) to Block Transcriptional Dysregulation and Toxicity in Huntington's Disease
(2012-08-16)Huntington’s disease (HD) is caused by expression of the huntingtin gene containing an expanded CAG repeat. N-terminal mutant huntingtin protein (N-mHtt) accumulates in the nucleus and impairs transcription of a subset of ...