Browsing by Subject "Diabetes"
Now showing items 1-9 of 9
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Age-, Sex-, and Diabetes-Determined Changes in the Structure and Mechanics of Human Sartorius Tendon Collagen
(2019-08-29)In an age where men and women are remaining physically active into the geriatric years, age-related changes in soft tissue injuries and healing are becoming more important to clinical care. Differences in structure and ... -
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CHEMERIN REGULATES ADIPOSITY AND ENERGY HOMEOSTASIS
(2011-11-08)Obesity, characterized by an excess of adipose tissue, is an established risk factor for cardiovascular disease and type II diabetes. Different mechanisms linking obesity with these comorbidities have been postulated but ... -
DIABETIC FOOT ULCERS: THE IMPACT OF POOR GLUCOSE CONTROL ON OUTCOMES OF TREATMENT
(2015)Diabetic foot ulcers are a difficult clinical entity. The healing is often delayed due to a number of factors. We also propose in this work the concept of the six detriments to healing a DFU (poor glycemic control, infection, ... -
Nova Scotia Medical Bulletin 31(8), 1952
(Medical Society of Nova Scotia, 1952) -
NUTRIENT REGULATION OF AUTOPHAGY IN THE HEART
(2016-09-02)Impaired cardiac metabolism in the obese-diabetic heart leads to glucolipotoxicity and ensuing cardiomyopathy. Glucolipotoxicity causes cardiomyocyte injury by increasing energy insufficiency and by dysregulating proteolysis. ... -
Regulation of Pancreatic Beta Cell Mass and Function by Proghrelin Derived Peptides
(2010-08-24)Proghrelin produces three proghrelin derived peptides (PGDP) known for their roles in glucose homeostasis: acylated ghrelin (AG), unacylated ghrelin (UAG), and obestatin (Ob). Only the receptor for AG, growth hormone ... -
THE ROLE OF LYSOPHOSPHATIDIC ACID AND AUTOTAXIN IN OBESITY-INDUCED CARDIAC INSULIN RESISTANCE
(2017-08-09)The metabolic changes to adipose tissue during obesity can induce cardiac insulin resistance. During obesity and diabetes, cardiac metabolic flexibility is reduced, which may lead to impaired ATP production, elevated ... -
The role of secretion associate ras-related GTPase 1b in skeletal muscle insulin signaling
(2023-04-24)Dysfunctional branched-chain amino acid (BCAA) catabolism increases intracellular branched-chain keto acids (BCKA), which inhibit insulin signaling. The discovery of Secretion Associated Ras-related GTPase-1B (Sar1b), a ...