Browsing by Subject "DNA methylation"
Now showing items 1-3 of 3
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THE BIOLOGICAL AND CLINICAL IMPLICATIONS OF PLASMINOGEN ACTIVATION IN PANCREATIC AND LUNG CARCINOMAS
(2019-11-28)The blood protein plasminogen circulates as an inactive precursor of the serine protease plasmin. Plasmin prevents aberrant formation of blood clots and protects individuals from vascular/tissue damage. Plasmin is also an ... -
EVALUATING INHIBITION OF DNA METHYLATION AND ALDH1A3 AS BREAST CANCER THERAPIES
(2020-09-01)Breast cancer is the most common form of cancer among Canadian women. Patients with triple-negative breast cancer (TNBC) have poor prognoses, with inherently more aggressive disease and limited treatment options. New ... -
Zebrafish Tools To Combat Acute Myeloid Leukaemia – The Nucleoporin 98 kiloDalton—Homeobox A9 (NUP98-HOXA9) Fusion Oncogene Drives Myeloproliferation By Upregulating DNA (Cytosine-5-)-Methyltransferase 1 (dnmt1)
(2018-02-12)We need to better understand the genetic mechanisms that transform normal blood cells into acute myeloid leukaemia (AML). Overall survival is improving for children and adults with AML, but traditional therapies can be ...