Browsing by Subject "Breast cancer"
Now showing items 1-15 of 15
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ADENOSINE AS AN ENVIRONMENTAL STRESSOR AFFECTING HSP27 AND CXCR4 IN EPITHELIAL CELLS
(2013-03-20)Solid tumours are a hostile tissue environment in which the cells are exposed to many stresses including hypoxia. One consequence of hypoxic conditions is an increase in extracellular levels of the purine nucleoside ... -
THE ANTICANCER ACTIVITY AND MECHANISMS OF ACTION OF JADOMYCINS IN MULTIDRUG RESISTANT HUMAN BREAST CANCER CELLS
(2018-09-28)Breast cancer is the most common cancer in women, and approximately one third of all breast cancers will ultimately metastasize. Metastatic breast cancer is classified as an incurable disease. The development of multidrug ... -
Characterizing metformin response and sensitivity biomarkers in breast cancer
(2018-09-28)The anti-diabetic drug metformin has been shown to exhibit broad in vitro and in vivo anti-neoplastic activity in various cancer types, including breast cancer. Despite numerous clinical trials ongoing, no targeted biomarkers ... -
Database Design for Sentinel Lymph Node Dissection of Breast Cancer
(2012-08-02)This 13-week internship project in Cancer Cancer Nova Scotia was aimed to design a database to collect information of sentinel lymph node dissection (SLND) for the credentialing of physicians who are interested to provide ... -
Development of a Clinical Rounds Module Under the CAISIS Platform
(2012-09-11)This paper presents and documents tasks and research performed during the author’s Master of Health Informatics internship at the Diagnostic Radiology Department in collaboration with the Nova Scotia Breast Screening Program ... -
DEVELOPMENT OF NECTIN-4-TARGETING ONCOLYTIC MEASLES VIROTHERAPY FOR THE TREATMENT OF BREAST AND LIVER CANCERS
(2021-07-27)Oncolytic viruses (OVs) are a rapidly emerging treatment platform for various types of cancer that offers several advantages over conventional anticancer therapeutics, including selectivity, potency, and targeted cell ... -
Development of reports containing health indicators generated with data extracted from cancer data management software
(2012-05-24)This report describes the Master of Health Informatics internship undertaken by James Wills at the Nova Scotia Breast Screening Program (NSBSP) in 2011. NSBSP is mandated to provide early detection of breast cancer through ... -
DISCOVERY AND CHARACTERIZATION OF A CANCER STEM CELL-ENRICHED LONG NON-CODING RNA IN TRIPLE-NEGATIVE BREAST CANCER
(2019-11-28)Triple-negative breast cancer (TNBC) patients face poor prognoses, possibly due to the presence of highly tumorigenic cancer stem cells (CSCs) within their tumors. The search for possible CSC targets is limited, but may ... -
Framework for a web-based breast imaging learning module built on the open-source CAISIS platform and integrated with the new Breast Imaging EMR and existing breast imaging information technology infrastructure at Capital District Health Authority
(2012-09-11)This report describes the work performed during an 18-week summer internship in the Department of Diagnostic Radiology at Capital District Health Authority (CDHA) by Master of Health Informatics (MHI) candidate Mete ... -
IN VITRO AND PRE-CLINICAL EVALUATION OF ANTI-METASTATIC ACTIVITY OF PHLORIDZIN DOCOSAHEXAENOATE (PZ-DHA) VERSUS TRIPLE-NEGATIVE BREAST CANCER
(2020-09-11)The World Health Organization identifies breast cancer as the most common cancer among women worldwide. Triple-negative breast cancer (TNBC) lacks receptors for estrogen (ER), progesterone (PR), and human epidermal growth ... -
Investigation into mechanisms of treatment resistance and heterogeneity in breast cancer and acute promyelocytic leukemia
(2021-09-14)Treatment failure remains a leading contributor to cancer related death despite considerable advances in detection and treatment approaches. Several factors contribute to treatment failure including the high degree of tumor ... -
An Investigation of the Anti-Cancer Effects of Apple Flavonoids Fraction 4 on Breast Cancer Cells
(2020-09-11)Cancer remains to be the one of the leading causes of death in Canada and the United States. In Canadian and American women, breast cancer is the second leading cause of cancer-related deaths behind lung cancer, despite ... -
Pepper-derived phytochemicals modulate metastatic processes in triple-negative breast cancer cells: a nanoparticle-based delivery approach
(2019-11-28)Metastasis and disease relapse are the primary determinant of cancer prognosis. The process of epithelial to mesenchymal transition (EMT) plays a crucial role in the induction of metastasis. Novel therapeutics are urgently ... -
Phytocannabinoids exert anti-cancer potential in preclinical in vitro models of breast cancer
(2021-08-26)There are a multitude of challenges that are faced in the treatment of breast cancer, such as resistance to chemotherapeutic agents and chemotherapy-induced adverse side effects. Cannabis sativa is used in cancer patients ... -
Scoping the Processes and Feasibility of a Synoptic Breast Pathology Reporting Module
(2012-09-11)This report presents the work that has been done in the Department of Diagnostic Radiology at Dalhousie University in collaboration with the Nova Scotia Breast Screening Program during the summer term from May to August ...