Browsing by Subject "5xFAD"
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Aberrant Behaviour and Neural Activity in the 5xFAD Mouse Model of Alzheimer's Disease: Exploring Behavioural and Psychological Symptoms of Dementia in a Mouse Model of Amyloid Pathology
(2023-08-30)The present work examines behavioural and psychological symptoms of dementia (BPSD)-like behaviours in the 5xFAD mouse model of Alzheimer’s disease (AD)-related amyloid pathology. In particular, this work reviews BPSD-like ... -
CHARACTERIZATION OF SOCIAL DEFICITS IN THE 5XFAD MOUSE MODEL OF ALZHEIMER'S DISEASE
(2019-11-28)The 5xFAD mouse strain is a double-transgenic Alzheimer’s disease (AD) model containing mutant APP (K670N/M671L, I716V, and V717I) and PS1 (M146L and L286V) genes. Mice expressing these mutations have rapid accumulation ... -
EXAMINING OLFACTORY LEARNING AND MEMORY IN THE TRIPLE TRANSGENIC AND FIVE TIMES MOUSE MODELS OF ALZHEIMER'S DISEASE USING AN OPERANT OLFACTOMETER
(2022-12-09)Alzheimer’s disease (AD) is a neurodegenerative disease that is the leading cause of dementia. Olfactory dysfunction is one of the earliest symptoms of AD, and mice show a remarkable ability to learn olfactory based tasks. ...