dc.contributor.author | Metlege, Valerie | |
dc.date.accessioned | 2024-08-30T13:32:28Z | |
dc.date.available | 2024-08-30T13:32:28Z | |
dc.date.issued | 2024-08-29 | |
dc.identifier.uri | http://hdl.handle.net/10222/84528 | |
dc.description.abstract | Pregnancy is a blood volume overload state accompanied by functional cardiac hypertrophy. Interestingly, cardiac remodeling in pregnancy is distinct in its absence of myocardial fibrosis, which is a common characteristic of pathological cardiac hypertrophy. The objective of this study was to characterize myocardial remodeling throughout pregnancy & post-partum in domestic cattle. The results identified mechanical adaptations of the myocardium during pregnancy – significant increases in UTS and extensibility. Accompanying those transformations were reductions in myocardial collagen thermal stability and mature crosslinking. Together, myocardial remodeling in pregnancy is a functional process allowing the myocardium to expand to accommodate blood volume overload, without compromising structural-mechanical integrity. This work has shown for the first time, pregnancy-induced myocardial collagen remodeling in cows. Importantly, this study suggests that myocardial remodeling leads to a permanent loosening of the myocardial collagen network in postpartum, with a persistent increase in extensibility and replacement of mature with immature collagen crosslinks. | en_US |
dc.language.iso | en | en_US |
dc.subject | collagen | en_US |
dc.subject | pregnancy | en_US |
dc.subject | volume overload | en_US |
dc.subject | myocardium | en_US |
dc.subject | postpartum | en_US |
dc.subject | cardiac remodeling | en_US |
dc.title | Remodeling of Myocardial Collagen in Domestic Cattle during Pregnancy and Postpartum | en_US |
dc.date.defence | 2024-08-23 | |
dc.contributor.department | School of Biomedical Engineering | en_US |
dc.contributor.degree | Master of Applied Science | en_US |
dc.contributor.external-examiner | n/a | en_US |
dc.contributor.thesis-reader | Dr. J. Michael Lee | en_US |
dc.contributor.thesis-reader | Dr. Geoffrey Maksym | en_US |
dc.contributor.thesis-reader | Dr. Samuel Veres | en_US |
dc.contributor.thesis-supervisor | Dr. Sarah Wells | en_US |
dc.contributor.ethics-approval | Received | en_US |
dc.contributor.manuscripts | Not Applicable | en_US |
dc.contributor.copyright-release | Yes | en_US |