dc.contributor.author | Campbell, Jacob W. | |
dc.contributor.author | Campbell | |
dc.date.accessioned | 2024-08-12T12:27:19Z | |
dc.date.available | 2024-08-12T12:27:19Z | |
dc.date.issued | 2024-08-08 | |
dc.identifier.uri | http://hdl.handle.net/10222/84395 | |
dc.description.abstract | This thesis provides a comprehensive overview of the synthetic procedures for late-stage functionalisation of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacenes (BODIPYs), specifically to append a tellurophene motif to unleash the photosensitisation capabilities of BODIPYs whilst providing a mass tag, via the tellurium atom, for mass cytometry.
The design and synthesis of the first tellurophene-appended BODIPY framework is realised. Investigational studies confirm tellurophene-appended BODIPYs exhibit desired photochemical characteristics for photosensitisation and the tellurium atom is traceable by mass cytometry. Tellurophenes are appended to BODIPYs via the boron centre and via the beta- and meso-positions of the dipyrrinato core. Further functionalisation involves appending the tellurophene-BODIPY framework to biological ligands, towards targeted therapy. | en_US |
dc.language.iso | en | en_US |
dc.subject | singlet oxygen | en_US |
dc.subject | tellurium | en_US |
dc.subject | photosensitizer | en_US |
dc.subject | photodynamic therapy | en_US |
dc.subject | mass cytometry reagent development | en_US |
dc.title | Synthesis and Evaluation of Tellurophene-appended BODIPYs | en_US |
dc.type | Thesis | en_US |
dc.date.defence | 2024-07-29 | |
dc.contributor.department | Department of Chemistry | en_US |
dc.contributor.degree | Doctor of Philosophy | en_US |
dc.contributor.external-examiner | Dr. Bryan Kiovisto | en_US |
dc.contributor.thesis-reader | Dr. Stephen Bearne | en_US |
dc.contributor.thesis-reader | Dr. Alex Speed | en_US |
dc.contributor.thesis-reader | Dr. Norman Schepp | en_US |
dc.contributor.thesis-supervisor | Dr. Alison Thompson | en_US |
dc.contributor.ethics-approval | Not Applicable | en_US |
dc.contributor.manuscripts | Yes | en_US |
dc.contributor.copyright-release | Yes | en_US |