dc.contributor.author | Esomchukwu, Vin-Boris Obinna | |
dc.date.accessioned | 2020-08-20T14:44:03Z | |
dc.date.available | 2020-08-20T14:44:03Z | |
dc.date.issued | 2020-08-20T14:44:03Z | |
dc.identifier.uri | http://hdl.handle.net/10222/79676 | |
dc.description.abstract | BACKGROUND. Hypothyroidism patients, unable to absorb oral levothyroxine rely on expensive and inconvenient intramuscular injections for life-time hormone replacement. OBJECTIVES: This project aimed to develop a non-invasive, less costly, and patient-friendly nasal delivery alternative using mucoadhesive polymers. METHODS: Nasal formulations were developed with carbopol, polycarbophil, chitosan, and hydroxypropyl methylcellulose (HPMC), respectively. The physicochemical properties and potential for nasal delivery were characterized. RESULTS: The formulation yield was high, with drug loading percentage of 72 -98% and mean particle size of less than 50 µm. The zeta-potential of the powder particles were electronegative and the differential calorimetric analysis and X-ray powder diffraction confirmed drug-polymer integration. The in vitro release studies demonstrated sustained levothyroxine release from the polymers over an extended period and their potential for nasal administration. CONCLUSIONS: Results of this study showed that carbopol, polycarbophil, chitosan, and HPMC can be used as sustained-release polymers for intranasal delivery of levothyroxine. | en_US |
dc.language.iso | en | en_US |
dc.subject | Levothyroxine | en_US |
dc.subject | Nasal formulation | en_US |
dc.subject | Hypothyroidism | en_US |
dc.subject | in vivo | en_US |
dc.title | DEVELOPMENT AND IN VITRO CHARACTERIZATION OF POLYMER-BASED NASAL FORMULATIONS OF LEVOTHYROXINE | en_US |
dc.date.defence | 2020-08-10 | |
dc.contributor.department | College of Pharmacy | en_US |
dc.contributor.degree | Master of Science | en_US |
dc.contributor.external-examiner | Thomas Ransom | en_US |
dc.contributor.graduate-coordinator | David Jakeman | en_US |
dc.contributor.thesis-reader | Tannis Jurgens | en_US |
dc.contributor.thesis-reader | Pollen Yeung | en_US |
dc.contributor.thesis-supervisor | Remigius Agu | en_US |
dc.contributor.thesis-supervisor | Syed Ali Imran | en_US |
dc.contributor.ethics-approval | Not Applicable | en_US |
dc.contributor.manuscripts | Not Applicable | en_US |
dc.contributor.copyright-release | Not Applicable | en_US |