Synthesis of symmetric meso-H dipyrrin hydrobromides from 2-formyl pyrroles
Abstract
The reaction of 2-formyl pyrroles in acidic methanol gives the corresponding symmetric, meso-H 4,6-dipyrrin hydrobromides. This convenient strategy involves initial deformylation under the acidic conditions, followed by immediate in situ reaction of the resulting α-free pyrrole with the remaining 2-formyl pyrrole in solution to give the dipyrrin hydrobromide salt in good yield.
Citation
Lund, K. L. A., & Thompson, A. (2014). Synthesis of Symmetric meso-H-Dipyrrin Hydrobromides from 2-Formylpyrroles. Synlett, 25(08), 1142-1144. DOI: 10.1055/s-0033-1341066